The answer
If you leave no SOL for fees, ordinary self-funded transactions may stop working, even when your wallet still holds USDC or other tokens.
What to do next
Leave a reasonable network-fee buffer based on your expected activity. A sponsored-fee app is an exception only when explicitly offered.
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Ledger hardware wallet
A hardware signing device to compare for supported Solana assets; it does not fix Solana network, token or smart-contract faults.
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Frequently asked questions
Does holding USDC automatically create free SOL for fees?
No. A token balance does not normally supply the chain’s native gas asset.