The answer
Not without satisfying the signatures and sighash conditions for the changed transaction. Under common SIGHASH_ALL signing, changing the destination invalidates earlier signatures.
What to do next
Examine the outputs and signing flags before approving any revised PSBT; do not assume partial signatures protect unusual sighash choices.
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Frequently asked questions
Does every Bitcoin signature commit to every output?
No. Bitcoin supports different sighash modes; the exact commitments depend on the mode and script type.
